METHODS FOR REGULATION OF IMMUNE REACTIVITY IN DOGS: a monograph

Abstract

In the modern conditions, immunological blood tests become extremely relevant in clinical practice. By using the results of these tests it is possible to quantify the indicators of non-specifi c resistance, cellular and humoral immunity, and when studying them in dynamics – to asses the effi ciency of treatment courses and develop methods to correct immunodefi ciencies. Studies conducted on small domestic animals in large cities have revealed signifi cant changes in immunological status, which leaves an imprint on the course of infectious and non-infectious pathology. The pharmaceutical industry off ers a wide range of immunomodulators that aff ect various parts of innate and adaptive immunity in animals. The key in clinical practice is to determine the individual sensitivity of the animal organism to an immunotropic agent and the prescription of a scheme for immunity correction. It should be noted that violations in the immune system may begin long before the clinical manifestation and manifest themselves under the exposure to a spontaneous biological stimulus. The above indicates the necessity to take into account the formation of adaptive immunity in dogs immediately after birth and, especially in critical periods of the development, emphasizing attention on the period of vaccine administration. The presented results of the author studies allow to gain knowledge about the ambiguity of the mechanisms of regulatory eff ect of immunoregulators with diff erent origin and plasmapheresis on the functioning of T and B cells in adaptive immunity. The results of the research presented in this monograph will not only complement the basic knowledge, but will also help veterinarians to better understand the immune system and how it is aff ected by various agents. The monograph will be useful to scientists and doctors, as well as to applicants for higher education in the fi eld of veterinary medicine.