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http://lib.osau.edu.ua/jspui/handle/123456789/3368| Title: | ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF VANILLIN DERIVATIVES |
| Authors: | Boiko Yu., Nesterkina M. V., Shandra A. A., Kravchenko I. A. |
| Keywords: | Vanillin derivatives, TRPA1 and TRPV1 receptors, analgesic activity, anti-inflammatory activity |
| Issue Date: | 2019 |
| Publisher: | Pharmaceutical Chemistry Journal |
| Citation: | Boiko Yu. A., Nesterkina M. V., Shandra A. A., Kravchenko I. A. Analgesic and anti-inflammatory activity of vanillin derivatives. Pharmaceutical Chemistry Journal, Vol. 53, No. 7, October, 2019. Р. 650-654. |
| Abstract: | The analgesic activity of 4-hydroxy-3-methoxybenzaldehyde (vanillin) derivatives with different pharmacophore groups were studied in vivo in models of chemically induced pain induced by subplantar administration of the TRP ion channel agonists capsaicin and allylisothiocyanate. The anti-inflammatory actions of vanillin derivatives were demonstrated in a model of carrageenan-induced edema. The analgesic and anti-inflammatory activities of vanillin and its derivatives were studied; these are linked with the effects of these substances on TRPA1 and TRPV1 receptors. |
| URI: | http://hdl.handle.net/123456789/3368 |
| Appears in Collections: | Бойко Юрій Олександрович |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Boiko (2).pdf | 528,66 kB | Adobe PDF | View/Open |
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