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dc.contributor.authorBoiko Yu.A., Kravchenko I.A., Shandra A.A., Boiko I.A.-
dc.date.accessioned2022-01-13T14:54:16Z-
dc.date.available2022-01-13T14:54:16Z-
dc.date.issued2017-
dc.identifier.citationBoiko Yu.A., Kravchenko I.A., Shandra A.A., Boiko I.A. Extraction, identification and anti-inflammatory activity of carotenoids out of Capsicum anuum L. J Herbmed Pharmacol. 2017;6(1):10-15.ru
dc.identifier.urihttp://hdl.handle.net/123456789/3371-
dc.description.abstractIntroduction: Carotenoids extracted from dried peppers were evaluated for their anti-inflammatory activities. Methods: Determining the concentration of carotenoids was carried out by spectrophotometry. Anti-inflammatory activity was studied on the model adjuvant-induced inflammation. In addition, the total number of white blood cells was studied by microscopic method in Gorjaev’s chamber. The biochemical parameters of blood - cholinesterase activity and total number of seromucoids in blood plasma were determined by the commercial test kits for rapid analysis Results: Peppers had a substantial carotenoid content: Ukrainian bitter 2076 ± 10 μg/g of sample in dry weight basis. The yellow fraction was 69.3%, the red fraction was 30.7%. The linear decrease of inflammatory edema in the course of therapeutic use of carotenoid extract ranged from 20% to 50%. The application of carotenoid extract reduced levels of activity acetylcholinesterase and concentration of seromucoids in serum of rats with adjuvant-induced inflammation. The use of carotenoid extract in rats with adjuvant-induced inflammation resulted in reduction of serum cholinesterase activity by 1.3 times and double decrease in the serum seromucoid concentration. Conclusion: Ukrainian bitter pepper carotenoid extract exhibited good anti-inflammatory activity, with inhibited adjuvant-induced oedema formation and progression. The results suggest that the carotenoids in dried Ukrainian bitter peppers have significant anti-inflammatory benefits and could be useful for pain and inflammation relief. The results of this study allow to recommend carotenoid extract for further investigation as active part of anti-inflammatory drugs.ru
dc.language.isoenru
dc.publisherJ Herbmed Pharmacolru
dc.subjectCarotenoids Adjuvant-induced inflammation Ukrainian bitter peppers Acetylcholinesterase Seromucoidru
dc.titleExtraction, identification and anti-inflammatory activity of carotenoids out of Сapsicum Anuum L.ru
dc.typeArticleru
Розташовується у зібраннях:Бойко Юрій Олександрович

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