Effectiveness of aldehyde disinfectant "DZPT-2” against the African swine fever virus

Abstract

We determined the application pattern of the innovative aldehyde disinfectant "DZPT-2" against the African swine fever virus (ASFV). Experiments on virucidal activity of the disinfectant were carried out in strict compliance with biosafety requirements for BSL-3 laboratory (State Institution "Ukrainian Research Anti-Plague Institute named after I.I. Mechnikov Ministry of Health of Ukraine"). We found that "DZPT-2" acts virulently on the causative agent of African swine fever at concentration of 0.5-1.0% of active substance at 1-hour exposure and consumption rate of 300-500 ml/m2. The "DZPT-2" shows virucidal properties against the ASFV at temperature up to minus 26-24 assumed that manufacturing of working solutions was made with 20% solution of antifreeze in concentration of 0.5-1.0% of the active substance at exposure of 1 hour and consumption rate of 300-500 ml/m2. Our results were confirmed during the bioassay as the most sensitive method for determining the viability of the pathogen. "DZPT-2" disinfectant can be used in anti-epizootic measures regarding the African swine fever and could effectively prevent and force the disinfection of livestock and veterinary control facilities.