ТРАНСДЕРМІН – НОВИЙ ПРОТИМАСТИТНИЙ ЙОДОВМІСНИЙ ПРЕПАРАТ

Abstract

В статті наведені дані щодо вивчення, місцевої дії, впливу на молочну залозу протимікробної дії та терапевтичної ефективності нового протимаститного йодовмісного препарату трансдерміну. Всебічне вивчення трансдерміну і отримані при цьому результати дозволяють пропонувати його як ефективний і безпечний засіб терапії при маститі лактуючих і сухостійних корів.

Work has been completed on the creation of an iodine-containing remedy of transdermal application, its physical and chemical properties, stability in long-term storage, local irritating effect, penetrative ability, harmlessness for the body, therapeutic efficacy in mastitis have been studied. A new generation of transdermine is the result of the chemical interaction of the polymeriodvismutsulphamide (PISC) and dimexide, taken in the ratio of 9:1. It is a pasty product of orange color with a barely perceptible garlic smell, a bitter-astringent taste. The experience of studying the physical stability of transdermine lasted 12 months; it did not reveal any significant changes in the monitored indicators (color, odor, taste, consistence, homogeneity, specific gravity). In experiments on laboratory animals (rabbits, white mice), transdermine in dilution with water 1:2 caused a weak and short-term conjunctival hyperemia, a general itching at subcutaneous application, which quickly disappeared. The transdermal applications of transdermine did not show an irritant effect on the parenchyma of the mammary gland of cows; this was confirmed by such highly sensitive tests as the counting of the number of somatic cells in milk, the titer of lysozyme. The control of the translocation of the active components of transdermine into the glandular part of the udder lactating cows was based on changes in the concentration of molecular iodine in milk after application of the drug on the skin of the mammary gland. As it turned out, in 6 hours after its application in a therapeutic dose, the concentration of iodine in milk doubled, and this level persisted for the next 12 hours. A further step was to study the bacteriostatic and bactericidal activity of transdermine, using passport strains of microbes, the main causative agents of mastitis. The basis for comparison was the data on the PISC, previously obtained by its authors-developers. Transdermine showed quite high antibacterial activity for all the strains tested, but the advantage over PIVS were not obvious. When comparing the therapeutic efficacy of transdermine and PIVS for catarrhal and purulent-catarrhal mastitis in cows that are in the before dry period, there is a certain advantage of transdermine, both in the percentage of recovery and the frequency rate of application of the remedy. Treatment with transdermine of dry cows with the same diagnoses provided a 100% recovery, and the course of treatment required only 2-3 applications of the remedy; this is 2 times less than in the before dry period. Being a highly effective and completely safe chemical and therapeutic veterinary remedy, transdermine could be widely used in surgical practice, and the most simple - application method.