СТАН ЕНДОГЕННОЇ ІНТОКСИКАЦІЇ ТА ПЕРЕКИСНОГО ОКИСНЕННЯ ЛІПІДІВ У СОБАК ЗА РІЗНИХ МЕТОДІВ ЛІКУВАННЯ ГНІЙНИХ РАН

Abstract

У статті наведено дані щодо використання янтаротерапії для собак з гнійними ранами. За результатами біохімічних досліджень виявлено вплив янтарної кислоти, розчину Реамберину та 5%-го розчину глюкози на рівень ендогенної інтоксикації та перекисного окиснення ліпідів за лікування гнійних ран у собак.

В статье приведены данные по использованию янтаротерапии для собак с гнойными ранами. По результатам биохимических исследований выявлено влияние янтарной кислоты, раствора Реамберина и 5%-го раствора глюкозы на уровень эндогенной интоксикации и перекисного окисления липидов при лечении гнойных ран у собак.

Summary.This article presents the results of biochemical analysis the use of succinic acid, Reamberin solution and 5% solution glucose in the treatment of purulent wounds in dogs.The material for the study were dogs with purulent wounds of the skin and soft tissues who were admitted to treatment at the surgical clinic of the Faculty of Veterinary Medicine of BilaTserkva, as well as clinically healthy animals. Were formed 3 groups animals. Animals I experimental group fed succinic acid at a dose of 0.1 g/kg individually for 5 days. Animals II experimental group were injected intravenously with Reamberin solution at a dose of 10 ml/kg, according to the current instruction for 5 days. Animals III groupwas the control group, which injected 5% glucose solution at a dose of 10 ml/kg for 5 days. Local treatment of purulent wounds in all groups of animals included primary surgical treatment, sanation with solutions of 3% hydrogen peroxide and chlorhexidine equally in the amount of 200 ml and introduction of ointment "Levomekol" twice on day.Blood collection in animals for the conduct of research was carried out prior to treatment, at the 3rd, 7th, 10th and 14th day of the experiment and in the group of clinically healthy animals. The most common diagnostic indicator of free radical oxidation in the wound run in dogs is the secondary product - malonic dialdehyde (MDA), which was determined by the method L.I.Andreeva. If he increases then it indicates on development of the pathological process, activation of the processes of POL and the development of endogenous intoxication of the body.For determine number of MSM in the blood plasma of dogs used spectrophotometric method by V.V.Nikolayichikom. The results of the biochemicalstudies, have shown that the MSM content in sick animals with surgical infection was twice high as in the case with of clinically healthy animals. MDA was also in greater numbers.When using succinic acid and a solution of Reamerinin dogs with purulent wounds, the level of endogenous intoxication in blood of animals on 4 days earlier than in animals of the control group.